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目的 :观察 HBs Ag阳性的肝细胞癌 (HCC)患者的血清乙肝标志物 ,并探讨不同标志物在评价慢性乙肝患者转归方面的意义。方法 :应用 EL ISA法分别检测 HBs Ag+ 的 30 0例 HCC和 10 0 0例慢性乙肝患者的血清 HBV的5项标志物。结果 :HCC组的抗 - HBe阳性率明显高于慢性乙肝组 ,而 HBe Ag阳性率明显低于慢性乙肝组 ,经统计学 U检验 ,结果均具有显著性差异 (P均 <0 .0 1)。结论 :HBe Ag阳性的成年慢性乙肝患者血清 HBe Ag减弱、消失及向抗HBe的慢性转化在理论上虽有预示病情好转的可能 ,但实际上往往是肝细胞癌发生的一个前期危险信号
Objectives: To observe the serum hepatitis B markers in patients with HBsAg positive hepatocellular carcinoma (HCC), and to explore the significance of different markers in evaluating the outcome of patients with chronic hepatitis B. Methods : Five markers of serum HBV were detected by EL ISA method in 300 cases of HCC and 100 cases of chronic hepatitis B patients. Results: The anti-HBe positive rate in HCC group was significantly higher than that in chronic hepatitis B group, while the positive rate of HBe Ag was significantly lower than that in chronic hepatitis B group. The results were statistically significant by U-test (P<0.01). . Conclusion: The reduction and disappearance of serum HBe Ag in HBeAg-positive adult chronic hepatitis B patients and the chronic transformation to anti-HBe may theoretically indicate that the condition may be improved, but in fact it is often an early danger signal of HCC.