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目的探讨辛伐他汀对老年患者高脂血症治疗的有效剂量和安全性。方法选择老年原发性高脂血症患者60例,予辛伐他汀20mg/d治疗,治疗过程中按预定的总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)达标水平调整药物用量。结果治疗后TC、LDL-C和三酰甘油分别下降33%、36%和27%(P均<0.01),HDL-C无显著变化。载脂蛋白A1升高18%,载脂蛋白B下降25%。LDL-C/HDL-C比值下降为1.95(P<0.01)。随访结束时,31%的患者服用辛伐他汀10mg/d,保持TC<4.7mmol/L和LDL-C<2.6mmol/L;69%的患者服用辛伐他汀5mg/d,保持TC<4.2mmol/L和LDL-C<2.1mmol/L。无明显不良反应发生。结论辛伐他汀对老年高脂血症治疗效果确切,所用剂量较小,安全性良好。
Objective To investigate the effective dose and safety of simvastatin in the treatment of elderly patients with hyperlipidemia. Methods Sixty elderly patients with primary hyperlipidemia were selected and treated with simvastatin 20 mg / d. The dosage of TC and LDL-C was adjusted during the course of treatment. . Results After treatment, TC, LDL-C and triglyceride decreased by 33%, 36% and 27% respectively (all P <0.01), HDL-C had no significant change. Apolipoprotein A1 increased 18% and apolipoprotein B decreased 25%. LDL-C / HDL-C ratio decreased to 1.95 (P <0.01). At the end of follow-up, simvastatin 10 mg / d was administered to 31% of patients, with TC <4.7 mmol / L and LDL-C <2.6 mmol / L; 69% of patients took simvastatin 5 mg / / L and LDL-C <2.1mmol / L. No significant adverse reactions occurred. Conclusion Simvastatin has definite effect on the treatment of senile hyperlipidemia, the dosage is small and the safety is good.