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内皮祖细胞(EPCs)是一种具有较强增殖能力的前体细胞,血管损伤或者缺血会刺激骨髓EPCs动员,迁移、归巢于相应的靶位,然后分化为内皮细胞(ECs),从而参与血管修复和血管新生。因此,EPCs的成功发现为缺血性和血管损伤性疾病的治疗提供了新策略。但是EPCs存在动员率低、靶向性较差和功能不全等问题。大量研究显示细胞因子对EPCs的动员、归巢、增殖和分化等均起着重要的调节作用,同时,通过调控细胞因子能改善EPCs的功能活性,因此选择合适的细胞因子来提高EPCs功能变得非常重要。现总结了近年来细胞因子对EPCs功能影响的研究进展,并提出有待解决的问题和作一定的展望。
Endothelial progenitor cells (EPCs) are precursors with strong proliferative capacity. Vascular injury or ischemia may stimulate bone marrow EPCs to mobilize, migrate, homing to the corresponding target sites and then differentiate into endothelial cells (ECs) Involved in vascular repair and angiogenesis. Therefore, the successful discovery of EPCs provides a new strategy for the treatment of ischemic and vascular injury. However, EPCs have such problems as low mobilization rate, poor targeting and insufficiency. A large number of studies have shown that cytokines play an important regulatory role in the mobilization, homing, proliferation and differentiation of EPCs. At the same time, the regulation of cytokines can improve the functional activity of EPCs. Therefore, selecting appropriate cytokines to improve the function of EPCs becomes Very important. Now summarizes the recent research on the impact of cytokines on the function of EPCs, and put forward some problems to be solved and make some prospects.