目的:探讨蒿芩清胆汤联合高强度聚焦超声(HIFU)治疗胆囊癌肝转移疗效及其对患者血清免疫球蛋白含量的影响。方法:将医院收治的86例胆囊癌肝转移患者作为研究对象,采用随机数字表法将其平均分为观察组及对照组。所有患者均给予HIFU治疗;观察组在对照组治疗的基础上同时给予蒿芩清胆汤进行治疗,每日1剂,分两次服用,共治疗8周。治疗后,对两组近期疗效及中医证候疗效进行评价;治疗前后,分别检测患者血清AST、ALT、ALP及TBIL含量;治疗前后,分别检测患者血清Ig G、Ig A及Ig M等免疫球蛋白含量。对所有患者进行2年的随访,并观察其6个月生存率、1年生存率及2年生存率;观察所有患者治疗期间各类不良反应。结果:治疗后,观察组近期疗效及中医证候疗效总有效率分别为88.1%和83.3%,均明显高于对照组的75.6%和70.7%,有显著性差异(P<0.05)。治疗后,观察组血清AST、ALT、ALP及TBIL含量均明显低于对照组,有显著性差异(P<0.05)。治疗后,观察组血清Ig G、Ig A及Ig M含量分别为(12.11±1.25)g/L、(2.97±0.40)g/L及(2.31±0.36)g/L,均明显高于对照组,有显著性差异(P<0.05)。观察组1年生存率及2年生存率分别为76.2%和64.3%,均明显高于对照组,有显著性差异(P<0.05)。治疗期间,所有患者均未出现严重不良反应。结论:蒿芩清胆汤联合HIFU治疗胆囊癌肝转移疗效确切,可有效提高患者免疫球蛋白含量,值得进行深入研究。 Objective: To investigate the curative effect of Haoqin Qing Dan Decoction combined with high intensity focused ultrasound (HIFU) on hepatic metastasis of gallbladder carcinoma and its effect on serum immunoglobulin content. Methods: Totally 86 cases of gallbladder carcinoma with liver metastasis admitted by the hospital were studied. The patients were divided equally into observation group and control group by random number table method. All patients were given HIFU treatment; the observation group was treated with the same time on the basis of the control group treated with Qingqin Qingdan Decoction, taking one day and taking two times in a total of eight weeks. After treatment, the two groups of short-term curative effect and curative effect of traditional Chinese medicine were evaluated. Before and after treatment, the levels of serum AST, ALT, ALP and TBIL were measured respectively. Before and after treatment, immunoglobulin Ig, Ig A and Ig M Protein content. All patients were followed up for 2 years and their 6-month survival rate, 1-year survival rate and 2-year survival rate were observed. All kinds of adverse reactions during the treatment were observed. Results: After treatment, the total effective rate of observation group and traditional Chinese medicine syndrome were 88.1% and 83.3% respectively, which were significantly higher than those of control group (75.6% and 70.7%, P <0.05). After treatment, the levels of AST, ALT, ALP and TBIL in the observation group were significantly lower than those in the control group (P <0.05). After treatment, the levels of Ig G, Ig A and Ig M in the observation group were (12.11 ± 1.25) g / L, (2.97 ± 0.40) g / L and (2.31 ± 0.36) g / L, , There was significant difference (P <0.05). The 1-year survival rate and 2-year survival rate in the observation group were 76.2% and 64.3%, respectively, which were significantly higher than those in the control group (P <0.05). During treatment, all patients did not have serious adverse reactions. Conclusion: Artemisia Qingqian Decoction combined with HIFU in the treatment of hepatic metastasis of gallbladder carcinoma is effective and can effectively improve the immunoglobulin content of patients, it is worth further study.