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自身免疫性脑炎(AE)是机体对神经元抗原成分发生异常免疫反应而导致的中枢神经系统的炎性疾病,表现为精神或行为异常,认知能力下降,可伴癫痫发作,诊断主要依靠临床表现、相关抗体检测和对免疫治疗的敏感性。作者主要介绍1例富亮氨酸胶质瘤失活1蛋白抗体阳性的AE,并对AE的临床表现、分类、特点、诊疗作一概述。
Autoimmune encephalitis (AE) is an inflammatory disease of the central nervous system caused by an abnormal immune response to neuronal antigen components. It manifests as mental or behavioral abnormalities, with decreased cognitive ability and may be associated with seizures. The diagnosis depends mainly on Clinical manifestations, related antibody testing, and sensitivity to immunotherapy. The author mainly introduced 1 cases of leuco-acid rich glioma inactivation 1 protein antibody-positive AE, and the clinical manifestations of AE, classification, features, diagnosis and treatment are summarized.