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目的:探讨非多囊卵巢综合征患者体重指数(BMI)对体外受精-胚胎移植(IVF-EF)结局的影响。方法:回顾性分析168例非多囊卵巢综合征患者的IVF-ET周期的结局。按BMI分为偏瘦组(BMI<18.5 kg/m2)、正常体重组(18.5 kg/m2≤BMI<24 kg/m2)、超重及肥胖组(BMI≥24 kg/m2)3组,比较3组患者的促性腺激素(Gn)用药天数和剂量,HCG注射日E2水平、获卵数、受精率、优胚率、种植率、临床妊娠率、流产率。结果:超重及肥胖组(BMI≥24 kg/m2)的Gn用量与其余两组相比有统计学差异(P<0.05),其余指标3组间无统计学差异(P>0.05)。结论:排除多囊卵巢综合征患者后,超重及肥胖患者与正常体重及偏瘦患者相比,在进行IVF-ET促排卵过程中需要更大的Gn用量,而超重及肥胖对IVF-ET的结局无显著影响。
Objective: To investigate the effect of body mass index (BMI) on the outcome of IVF-EF in non-PCOS patients. Methods: A retrospective analysis of 168 patients with non-PCOS IVF-ET cycle outcomes. BMI was divided into three groups according to BMI (18.5 kg / m2), normal weight group (18.5 kg / m2≤BMI <24 kg / m2) and overweight and obesity group (BMI≥24 kg / m2) Days and doses of gonadotropin (Gn), E2 level on HCG injection day, number of oocytes retrieved, fertilization rate, excellent embryo rate, implantation rate, clinical pregnancy rate and miscarriage rate were observed. Results: There was a significant difference in the amount of Gn between overweight and obesity group (BMI≥24 kg / m2) compared with the other two groups (P <0.05). There was no significant difference among the other three groups (P> 0.05). CONCLUSIONS: After excluding patients with polycystic ovary syndrome, overweight and obese patients required greater Gn use during IVF-ET ovulation compared with patients with normal body weight and lean body mass, whereas overweight and obesity did not significantly affect IVF-ET No significant effect on outcome.