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中药材经过不同方法炮制后将改变其中物质的组成和含量,从而影响药理活性。利用电感耦合等离子体发射光谱法(ICP-AES),原子吸收光谱法(AAS)和原子荧光光谱法(AFS)全面扫描并分析民族药小茴香生品及其9种不同炮制品中与人体健康和生命相关的常量元素,微量元素和重金属的种类及含量。结果显示,3种光谱分析方法均能快速准确地分析中药材中各种元素含量及其变化趋势,从小茴香中共检测出32种元素,与生品相比,不同炮制方法使某些元素发生了明显不同的变化,表明炮制方法与元素变化有较强的相关性,说明辅料不仅能改变元素含量而且能与有效成分一道发挥协同治疗疾病,并首次发现炮制将导致重金属Hg的含量急剧增高,临床使用清炒小茴香时存在重大安全隐患。实验拓宽了光谱法在中药安全性评价中的应用。
After processing Chinese herbal medicines through different methods, the composition and content of the substances will be changed, thereby affecting the pharmacological activities. Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES), Atomic Absorption Spectrometry (AAS) and Atomic Fluorescence Spectrometry (AFS) were used to scan and analyze the health and safety of ethnic fennel products and their 9 different processed products. The types and contents of macro-elements, trace elements, and heavy metals associated with life. The results show that the three kinds of spectral analysis methods can quickly and accurately analyze the contents of various elements in Chinese herbal medicines and their changing trends. A total of 32 elements were detected from cumin. Compared with raw materials, different processing methods have caused certain elements to occur. Obviously different changes indicate a strong correlation between processing methods and elemental changes, indicating that excipients can not only change the element content but also work synergistically with the active ingredient to treat diseases, and it was first discovered that concocting will lead to a sharp increase in the content of heavy metal Hg, clinically There is a major security risk when using fennel. The experiment broadens the application of spectroscopy in the evaluation of Chinese medicine safety.