肿瘤坏死因子(TNF)在体内外均具有很强的的抗肿瘤活性。研究表明TNF对不同肿瘤细胞的细胞毒作用并不相同,而且有些肿瘤细胞对TNF甚至具有抵抗性。至今该抗性产生的机理仍不清楚。本文作者采用基因转染技术研究了肿瘤细胞表达内源 Tumor necrosis factor (TNF) has a strong anti-tumor activity both in vitro and in vivo. Studies have shown that the cytotoxic effect of TNF on different tumor cells is not the same, and some tumor cells are even resistant to TNF. The mechanism by which this resistance has so far remained unclear. The authors used gene transfection techniques to study the endogenous expression of tumor cells