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用免疫组化法对20例正常子宫内膜、22例增生性内膜及41例子宫内膜癌标本进行凋亡抑制基因（B－Celllymphoma／leukemia－2，BCL－2）、增殖细胞核抗原（Prolifer－atingcellnuclearantigen，PCNA）蛋白检测，以探讨其在子宫内膜病变发生、发展中的作用。结果两者表达率（20．0％、90．9％、31．7％；40．0％、72．7％、97．6％）均存在显著差异。子宫内膜癌组织中，BCL－2染色强度与组织学分级无相关性，PCNA染色则有相关性，且1级与3级间存在差异。两种蛋白表达间无相关性。提示BCL－2蛋白在正常内膜周期性变化及增生性病变的发生、发展中发挥作用，并可能为进一步基因异常改变提供有利条件，而在子宫内膜癌中其表达可能与细胞分化有关。PCNA有助于了解内膜病变的生物学行为，有可能成为判定子宫内膜癌恶性程度及预后的客观指标之一。
Immunohistochemistry was used to detect the expression of B-Cell Lymphoma / leukemia-2 (BCL-2) and proliferating cell nuclear antigen (PCNA) in 20 cases of normal endometrium, 22 cases of proliferative endometrium and 41 cases of endometrial carcinoma Prolifer-atingcell nuclearantigen, PCNA) protein in order to explore its role in the occurrence and development of endometrial lesions. Results The expression rates of the two groups were significantly different (20.0%, 90.9%, 31.7%, 40.0%, 72.7%, 97.6%). In endometrial carcinoma, there was no correlation between BCL-2 staining intensity and histological grade, but PCNA staining was correlated with grade 1 and 3. No correlation between the two protein expression. These results suggest that BCL-2 protein may play a role in the occurrence and development of normal endometrial and proliferative lesions, and may provide favorable conditions for further gene abnormalities. However, its expression may be related to cell differentiation in endometrial carcinoma. PCNA helps to understand the biological behavior of endometrial lesions, it may become one of the objective indicators to determine the degree of malignancy and prognosis of endometrial cancer.