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目的:探讨川芎嗪注射液对冠心病(CHD)心绞痛患者临床症状及血液流变学的影响。方法:选择2014年3月至2016年3月在我院进行治疗的CHD心绞痛患者60例,按随机数字表法分为实验组和对照组各30例,对照组患者给予常规治疗,实验组患者在常规治疗基础上加用川芎嗪注射液治疗,两组患者均治疗20 d,比较两组患者临床疗效及治疗前后心绞痛症状、血液流变学指标和血脂指标。结果:实验组治疗后的总有效率高于对照组(P<0.05)。两组治疗后心绞痛发作次数、发作时长均减少,且实验组少于对照组(P<0.05)。治疗后,两组的全血黏度、血浆黏度、红细胞聚集指数、纤维蛋白原(Fib)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均低于治疗前,且实验组低于对照组,(P<0.05)。结论:川芎嗪在治疗CHD心绞痛方面具有显著的疗效,不仅能够有效改善患者心绞痛症状,还能改善血液流变学异常情况,因此值得临床推广使用。
Objective: To investigate the effect of ligustrazine injection on clinical symptoms and hemorheology in patients with coronary heart disease (CHD) angina pectoris. Methods: Sixty patients with CHD angina pectoris who were treated in our hospital from March 2014 to March 2016 were randomly divided into experimental group and control group according to the random number table method, 30 patients in the control group and 30 patients in the control group were given routine treatment. Patients in the experimental group On the basis of conventional treatment, ligustrazine injection was given. Both groups were treated for 20 days. The clinical efficacy, angina pectoris, hemorheological indexes and serum lipids were compared between the two groups before and after treatment. Results: The total effective rate of experimental group after treatment was higher than that of control group (P <0.05). The number of episodes of angina and the duration of attack in both groups decreased after treatment, and the experimental group was less than the control group (P <0.05). After treatment, the whole blood viscosity, plasma viscosity, erythrocyte aggregation index, fibrin (Fib), total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) Before treatment, the experimental group was lower than the control group (P <0.05). Conclusion: Tetramethylpyrazine has significant curative effect in the treatment of CHD angina, which can not only effectively improve the angina pectoris symptoms but also improve the abnormality of hemorheology. Therefore, it is worthy of clinical promotion.