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本文用内腾周幸法,测定145例不同年龄组正常人血浆过氧化脂质(Lipoperoxides,LPO)水平,用肾上腺素自氧化法,测定其红细胞内超氧化物歧化酶(Superoxide Dismutase,SOD)的比活性,共计儿童组39例,18～39岁58例以及40～65岁组48例。结果表明,随着年龄的增加,正常人血浆LPO水平逐渐升高,而红细胞SOD比活性则逐渐降低,均有显著性差异(P值均<0.001)。48例冠心病患者与年龄相近的正常人组相比较,前组的血浆LPO浓度高于正常人,而其红细胞SOD比活性则低于正常人(P值分别<0.01,0.001)。该两项生化指标的检测结果.为衰老及冠心病发生机制的自由基学说提供了实验依据。
In this study, we determined the levels of plasma lipoperoxides (LPO) in 145 healthy adults of different ages by the method of Teng-Xing-Zhou-Xing. The levels of superoxide dismutase (SOD) in erythrocytes were determined by adrenaline autoxidation Specific activity, a total of 39 cases of children, 58 cases of 18 to 39 years old and 40 to 40 years old group of 48 cases. The results showed that with the increase of age, plasma LPO levels in normal subjects gradually increased, while SOD activity in erythrocytes decreased gradually, both of which were significantly different (P <0.001). 48 patients with coronary heart disease compared with the normal age group, the plasma LPO concentration in the former group than in normal subjects, and the erythrocyte SOD activity was lower than normal (P value <0.01, 0.001). The two biochemical indicators of the test results for the mechanism of aging and coronary heart disease free radical theory provides an experimental basis.