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目的:检测c-fos蛋白和c-jun蛋白在宫颈癌、CIN以及宫颈炎组织中的表达,并探讨其意义。方法:免疫组织化学S-P法检测23例宫颈癌、11例CINIII、13例CINII、20例CINI、10例宫颈炎组织标本中c-fos和c-jun蛋白的表达。结果:①c-fos蛋白在宫颈癌、CINIII、CINII和CINI以及宫颈炎中的表达分别为82.6%(19/23)、65.2%(7/11)、46.2%(6/13)、35.0%(7/20)、0.0%(0/10);②c-jun蛋白在宫颈癌、CINIII、CINII、CINI以及宫颈炎中的阳性表达率分别为78.3%(18/23)、54.5%(6/11)、38.5%(5/13)、30.0%(6/20)、0.0%(0/10);③c-fos和c-jun在宫颈癌、宫颈癌前病变、宫颈炎中的表达均有显著差异(H=0.000,P<0.05);经秩相关检验分析,c-fos和c-jun在宫颈炎、宫颈癌前病变、宫颈癌中的表达呈正相关(r=0.581,P=0.000)。结论:c-fos和c-jun蛋白的表达可能与宫颈癌前病变、宫颈癌的发生密切相关,两者可能在宫颈癌的发生过程中起一定的协同作用。
Objective: To detect the expression of c-fos protein and c-jun protein in cervical cancer, CIN and cervicitis, and to explore its significance. Methods: The expressions of c-fos and c-jun proteins in 23 cases of cervical cancer, 11 cases of CINIII, 13 cases of CINII, 20 cases of CINI and 10 cases of cervicitis were detected by immunohistochemical S-P method. Results: ① The expressions of c-fos protein in cervical cancer, CINIII, CINII and CINI and cervicitis were 82.6% (19/23), 65.2% (7/11), 46.2% (6/13) and 35.0% The positive rates of c-jun protein in cervical cancer, CINIII, CINII, CINI and cervicitis were 78.3% (18/23) and 54.5% (6/11), respectively ), 38.5% (5/13), 30.0% (6/20) and 0.0% (0/10), respectively. ③ The expressions of c-fos and c-jun in cervical cancer, precancerous lesions of cervix and cervicitis were significantly different There was a positive correlation between the expression of c-fos and c-jun in cervicitis, cervical precancerous lesions and cervical cancer (r = 0.581, P = 0.000) by rank correlation analysis (H = 0.000, P <0.05). CONCLUSION: The expressions of c-fos and c-jun proteins may be closely related to the occurrence of cervical precancerous lesions and cervical cancer. Both of them may play a synergistic role in the carcinogenesis of cervical cancer.