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近几年,我们遇到9例化脓性脑膜炎患者静滴大剂量青霉素G致小儿神经毒性反应(男6例、女3例,年龄3个月～2岁)。分别以青霉素G钠60～100万U/(kg·d)一次静滴(2～3小时滴毕)或分两次静滴(间歇1～1.5小时),在治疗的第10～17天发生神经毒性反应(发生于静滴中1例,滴毕2小时2例,4小时4例,6小时2例)。9例连续观察3天均有同样发作,并作相应检查排除了其它原因。9例表现为不同程度抽风,呈阵挛性或强直性发作;每日发作1～3次,每次持续20分钟至1小时;经停用青霉素G6例、减量3例而毒性反应消失。3例抽风发作后行头颅CT检查阴性,7
In recent years, we encountered 9 patients with purulent meningitis intravenous infusion of large doses of penicillin G-induced neurotoxic reactions in children (6 males and 3 females, aged 3 months to 2 years). They were given intravenous infusion of penicillin G 60-1 million U / (kg · d) (two to three hours) or intravenous infusion (two to three hours intermittently) on the 10th to 17th day after treatment Neurotoxic reaction (occurred in 1 case of intravenous drip, 2 cases 2 hours after dripping, 4 cases 4 hours, 2 cases 6 hours). 9 cases of continuous observation of 3 days have the same attack, and check out the other reasons excluded. 9 cases showed varying degrees of ventilation, was clonic or tonic seizures; attack 1 to 3 times a day, each duration of 20 minutes to 1 hour; after stopping penicillin G6 cases, reduction of 3 cases and the toxic reaction disappeared. Three cases of craniocerebral trauma after CT examination negative, 7