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目的:探讨肾恶性肿瘤罕见类型肾梭形细胞癌的临床特点、治疗及预后。方法:报告1例肾梭形细胞癌患者的临床资料,并结合文献进行讨论。结果:术前根据相关检查、结合病史及入院查体诊断左肾盂肿瘤、左肾无功能,行左肾盂癌根治术,术后病理诊断为肾梭形细胞癌。免疫组化结果示VIM(+)、CD10(+)、EMA(小灶+)、SMA(局灶+)、CD34(血管+)、CK(-)、RCC(-)、PAX-2(-)、ALK(-)、S-100(-)、Ki67(30%+)。患者术后4个月死于多发性转移。结论:肾梭形细胞癌是一种高度恶性且临床上罕见的肾细胞癌,确诊有赖于典型病理表现及免疫组化,治疗以根治性肾切除术为主,放化疗等效果不佳,预后差。
Objective: To investigate the clinical features, treatment and prognosis of rare type of renal spindle cell carcinoma of renal cell carcinoma. Methods: The clinical data of one case of patients with renal spindle cell carcinoma were reported and discussed in the literature. Results: Preoperative diagnosis of left renal pelvis tumor based on related examination, combined with medical history and admission examination, left renal pelvis cancer radical surgery, postoperative pathological diagnosis of renal spindle cell carcinoma. Immunohistochemical results showed that VIM (+), CD10 (+), EMA (small focus +), SMA , ALK (-), S-100 (-), Ki67 (30% +). The patient died of multiple metastases 4 months after surgery. Conclusion: FsF is a highly malignant and clinically rare type of renal cell carcinoma. The diagnosis depends on the typical pathological findings and immunohistochemistry. The treatment is mainly based on radical nephrectomy. The radiotherapy and chemotherapy are ineffective and the prognosis difference.