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精子发生是一个高度调控的转录、翻译和翻译后过程[1]。精原干细胞在婴儿出生后就开始了其分化过程:经过精原细胞有丝分裂和精母细胞减数分裂之后,所形成的单倍体圆形精子细胞通过精蛋白替代组蛋白完成染色质浓缩和细胞核重塑过程,最终形成了具有特定表观遗传修饰的成熟精子[2]。近期的研究表明,虽然人类基因组广泛转录,但大部分
Spermatogenesis is a highly regulated transcription, translation and post-translational process [1]. Spermatogonial stem cells begin to differentiate after the baby is born: After the spermatogonial mitosis and spermatocyte meiosis, the formed round haploid circular spermatids complete chromatin condensation and nucleus by protamine instead of histone Remodeling process, the final formation of a specific epigenetic modification of mature sperm [2]. Recent studies show that although the human genome is widely transcribed, most are