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目的探讨阿托伐他汀钙对高血压合并动脉粥样硬化患者的疗效。方法选择2014年1月至2015年1月经颈部彩色多普勒检查符合诊断标准的原发性高血压并动脉粥样硬化患者41例为研究组,选取同期无颈动脉粥样斑块的原发性高血压患者40例为对照组,观察两组治疗前及研究组治疗后血压、颈总动脉内膜中层厚度(IMT)、血管内皮功能以及氧化应激指标的变化。结果治疗前研究组IMT、血管性血友病因子(v WF)、内皮素(ET-1)、丙二醛(MDA)高于对照组,NO、超氧化物歧化酶(SOD)水平低于对照组,差异有统计学意义(P<0.05)。治疗后研究组IMT、v WF、ET-1、MDA较治疗前降低,NO、SOD水平较治疗前升高,差异有统计学意义(P<0.05)。结论阿托伐他汀能有效逆转氧化应激所致的损伤,降低氧化应激水平,改善血管内皮功能,治疗高血压并动脉粥样硬化效果明显。
Objective To investigate the effect of atorvastatin calcium on patients with hypertension and atherosclerosis. Methods From January 2014 to January 2015, 41 patients with primary hypertension and atherosclerosis who underwent color Doppler ultrasound examination of the neck were selected as the study group. The patients with the same carotid atherosclerotic plaque Forty patients with essential hypertension were selected as control group. The changes of blood pressure, carotid intima-media thickness (IMT), endothelial function and oxidative stress indexes in both groups before and after treatment were observed. Results Before treatment, the levels of IMT, vWF, ET-1 and MDA in the study group were higher than those in the control group, and the levels of NO and SOD were lower than Control group, the difference was statistically significant (P <0.05). After treatment, the levels of IMT, vWF, ET-1 and MDA in the study group were lower than those before treatment, and the levels of NO and SOD were higher than those before treatment (P <0.05). Conclusions Atorvastatin can effectively reverse the oxidative stress-induced injury, reduce the level of oxidative stress, improve the function of vascular endothelium, and treat hypertension with obvious atherosclerosis.