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本研究选择先天性血管病变患者６５例，根据临床及病理检查，按Ｍｕｌｉｋｅｎ和Ｇｌｏｗａｃｋｉ的新分类诊断分组，每例抽取静脉血２ｍｌ，应用典型的双抗体放射免疫法测定血清雌二醇Ｅ２水平，结果表明：①血管瘤和血管畸形及正常对照各组的男、女患儿血清Ｅ２水平无显著性差异（Ｐ＞０．０５），其血清Ｅ２水平与性别无关。②血管瘤和血管畸形患儿血清Ｅ２水平之间统计学差异显著（Ｐ＜０．０１），说明血管瘤血清Ｅ２水平明显高于血管畸形血清Ｅ２水平。血清Ｅ２水平可作为血管瘤和血管畸形的鉴别诊断指标之一。
This study selected 65 patients with congenital vascular disease, according to clinical and pathological examination, according to the classification of Muliken and Glowacki new diagnosis of subgroups, venous blood samples were extracted 2ml, the typical double antibody radioimmunoassay method for the determination of serum estradiol E2 levels, The results showed that: (1) There was no significant difference in serum E2 levels between male and female children with hemangiomas and vascular malformations and normal controls (P> 0.05). Serum E2 level had no relation with sex. ② There was a significant difference in serum E2 levels between hemangiomas and vascular malformations (P <0.01), indicating that the level of serum E2 in hemangiomas was significantly higher than that in serum of vascular malformations. Serum E2 levels can be used as a differential diagnosis of hemangiomas and vascular malformations.