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用双抗体夹心ＥＬＩＳＡ法对７２例肾移植患者血清可溶性白介素２（ＳＩＬ－２Ｒ）值进行连续动态监测，结果术前尿毒症患者ＳＩＬ－２Ｒ值较正常人高，术后迅速下降，排斥反应时ＳＩＬ－２Ｒ值明显升高，与血清肌酐（Ｃｒ）有明显一致性，并较临床症状的出现和血Ｃｒ升高早１～３天，敏感性达９４．４％，特异性达９１．７％，并能与ＣｓＡ中毒相鉴别。术前ＳＩＬ－２Ｒ水平对术后发生排斥反应有一定预示作用，连续动态监测对确定患者免疫状态、判断疗效和预后也都有重要意义。用ＥＬＩＳＡ法检测ＳＩＬ－２Ｒ是一种快速、敏感无创伤性的免疫学方法，用于临床肾移植研究价值较大。
Serum soluble interleukin-2 (SIL-2R) in 72 renal transplant recipients was monitored by double antibody sandwich ELISA. The results showed that SIL-2R in patients with uremia before operation was significantly higher than that in controls The level of SIL-2R was significantly higher than that of serum creatinine (Cr). Compared with the appearance of clinical symptoms and the rise of blood Cr, the SIL-2R level was as high as 94.4% and the specificity was 91.7 %, And can differentiate with CsA poisoning. The level of SIL-2R preoperatively has a certain predictive value for postoperative rejection. Continuous dynamic monitoring is also of great significance in determining the patient’s immune status and judging the efficacy and prognosis. SIL-2R is a rapid, sensitive and noninvasive immunological method for detecting SIL-2R by ELISA, which is of great value in clinical renal transplantation.