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探讨乳腺癌的微卫星不稳定性及其与乳腺癌临床病理的关系,寻找更有效的判断乳腺癌预后的分子标志,为乳腺癌的发生及预后判断提供理论依据。乳腺癌中普遍存在着MSI,并且MSI更多发生在有腋窝淋巴结转移、HER2表达及临床晚期的病例中,提示预后较差的乳腺癌病例中MSI的发生率更高,MSl可能是判断乳腺癌临床分期的一个分子标志,有助于对乳腺癌的预后评估。
To investigate the microsatellite instability of breast cancer and its relationship with the clinicopathological features of breast cancer, to find more effective molecular markers to determine the prognosis of breast cancer, provide a theoretical basis for the occurrence and prognosis of breast cancer. The prevalence of MSI in breast cancer, and MSI more in axillary lymph node metastasis, HER2 expression and late clinical cases, suggesting that poor prognosis in patients with a higher incidence of MSI, MSl may be to determine the breast cancer A molecular marker of clinical stage contributes to the prognosis of breast cancer.