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目的:探讨血管细胞粘附分子-1(VCAM-1)的检测在儿童过敏性紫癜(AP)早期肾损伤中的临床意义。方法:选择明确诊断为AP患儿85例,均为早期无肾损害的AP病儿。根据第七版诸福棠实用儿科学有关章节的诊断标准和随访结果,进一步将研究对象分为有肾损害AP为APN组,无肾损害AP为AP组,于同时间、同群体中选择健康儿童35名为对照组。应用ELISA法分别检测三组患儿早期无肾损害时血VCAM-1的含量,分析血VCAM-1在儿童过敏性紫癜早期肾损伤中的临床意义。结果:APN组血VCAM-1水平均高于AP组和正常对照组;AP组亦高于正常对照组,差异均有统计学意义(P<0.01)。结论:对早期无肾损害的AP病儿,检测血浆VCAM-1对AP发生APN的预后诊断有重要的临床意义。
Objective: To investigate the clinical significance of detection of vascular cell adhesion molecule-1 (VCAM-1) in early renal injury in children with Henoch-Schonlein purpura (AP). Methods: A total of 85 AP patients diagnosed as AP were selected, all of whom were AP children without early renal damage. According to the diagnostic criteria and the follow-up results of the relevant chapters of the 7th edition of Zhu Beitang’s practical pediatrics, the subjects were further divided into APN patients with renal damage AP, AP patients without renal damage, and at the same time, healthy persons 35 children as a control group. The levels of serum VCAM-1 in the early stage of kidney-injured children were detected by ELISA, and the clinical significance of blood VCAM-1 in the early stage of renal damage in children with Henoch-Schonlein purpura was analyzed. Results: The level of VCAM-1 in APN group was higher than that in AP group and normal control group. The AP group was also higher than that in normal control group (P <0.01). Conclusion: The detection of plasma VCAM-1 in AP children with early renal damage has important clinical significance in the prognosis of APN.