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肾上腺髓质素2是近年来新发现的一种小分子活性肽,其作为心血管、肾脏、肺脏等重要脏器的内源性保护因子,参与机体内环境稳态的调节,具有降低血压、抗动脉粥样硬化、抗纤维化、抗凋亡、保护器官缺血再灌注损伤、调控血管生成等作用,在多种脏器和系统的病理生理过程中发挥着多样而强大的生物学效应。本文将对肾上腺髓质素2的生物学特性、组织分布、受体结合及其在心肺肾等重要脏器发挥的生物学效应进行总结,以加深对肾上腺髓质素2生物学作用机制的了解和认识。
Adrenomedullin 2 is a newly discovered small molecule active peptide in recent years. As an endogenous protective factor of cardiovascular, kidney, lung and other important organs, adrenomedullin 2 is involved in the homeostasis of the body environment and has the functions of lowering blood pressure, Anti-atherosclerosis, anti-fibrosis, anti-apoptosis, protection of organ ischemia-reperfusion injury and regulation of angiogenesis. It plays a diverse and powerful biological role in the pathophysiology of various organs and systems. This article will summarize the biological characteristics of adrenomedullin 2, tissue distribution, receptor binding and its biological effects in important organs such as heart, lung and kidney to deepen the understanding of the mechanism of adrenomedullin 2 biological effects And know.