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目的观察老年人非甾体抗炎药(NSAIDs)相关性胃十二指肠损伤的胃镜特点及临床表现。方法将167例我院胃镜下发现的老年性胃、十二指肠粘膜损伤患者,根据胃镜发现胃、十二指肠粘膜损伤时是否正在服NSAIDs分为A组77例(服用NSAIDs组)和B组90例(未服用NSAIDs组)。观察两组患者临床表现和胃镜下特点。结果 A组患者胃、十二指肠粘膜损伤所致相关临床表现与胃镜检查结果不一致,A组患者内镜下常伴有较严重的多发、巨大溃疡等,而缺乏典型的胃肠粘膜损伤的上消化道症状。结论长期使用NSAIDs可引起NSAIDs相关性胃十二指肠损伤,严重者可导致消化性溃疡、胃肠穿孔和出血等严重并发症。
Objective To observe the endoscopic features and clinical manifestations of gastroduodenal injury associated with non-steroidal anti-inflammatory drugs (NSAIDs) in the elderly. Methods A total of 167 patients with senile gastric mucosa and duodenal mucosal lesions under gastroscopy in our hospital were enrolled and divided into 77 A (NSAIDs) and A B group 90 cases (not taking NSAIDs group). The clinical manifestations and endoscopic features of the two groups were observed. Results A group of patients with stomach and duodenal mucosal injury related clinical findings inconsistent with endoscopy, A group of patients with endoscopic often accompanied by more serious, huge ulcers, etc., and the lack of typical gastrointestinal mucosal injury Upper gastrointestinal symptoms. Conclusion Long-term use of NSAIDs can cause NSAIDs-related gastroduodenal injury, severe cases can lead to peptic ulcer, gastrointestinal perforation and bleeding and other serious complications.