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病毒性脑炎是一种严重的中枢神经系统(CNS)急性感染性疾病,早期诊断和治疗对降低疾病的病死率和致残率有非常重要的意义。本文拟就病毒性脑炎的生物学诊断方法及临床意义作一简要综述。1 抗体检测 脑脊液(CSF)中单纯疱疹病毒(herpes simplex virus,HSV)抗体滴度升高4倍以上或出现血清转化,以及血清与CSF抗体滴度比≤20,提示HSV脑感染,但须同时检测CSF白蛋白含量以排除通过血-脑脊液屏障从血液被动扩散CSF的HSV特异性抗体。一般认为鞘内抗体合成反映HSV中枢神经系统(CNS)感染,主要用于回顾性诊断,其临床价值不高,因仅少数病人在疾病早期发生对HSV的免疫反应[1]。但
Viral encephalitis is a serious central nervous system (CNS) acute infectious disease, early diagnosis and treatment to reduce disease mortality and morbidity are very important. This article is about the biological diagnosis of viral encephalitis and clinical significance of a brief review. 1 antibody detection Herpes simplex virus (CSF) antibody herpes simplex virus (HSV) more than 4 times the titers or seroconversion, and serum and CSF antibody titer ratio ≤ 20, suggesting HSV brain infection, but at the same time CSF albumin levels were tested to exclude HSV-specific antibodies that passively diffuse CSF from the blood through the blood-brain spinal barrier. It is generally believed that the synthesis of intrathecal antibodies reflects the infection of the HSV central nervous system (CNS) and is mainly used for retrospective diagnosis. Its clinical value is not high because only a few patients have an immune response to HSV early in the disease [1]. but