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目的分析艾滋病(AIDS)合并侵袭性真菌感染的发生情况及临床特点,为其诊治提供参考。方法回顾性分析85例AIDS患者的临床资料,总结侵袭性真菌感染的发病情况及临床特点。结果85例AIDS患者继发侵袭性真菌感染35例,感染率为41．2％,感染部位以消化道为主,占44．4％,致病菌以白念珠菌(白假丝酵母)为主,占57．4％,侵袭性真菌感染病例主要发生于CD4~+T淋巴细胞计数＜100个/μl的患者,占71．8％。35例患者中27例治愈,8例死亡。结论侵袭性真菌感染是AIDS患者主要的机会性感染之一,其发生与CD4~+T淋巴细胞计数密切相关,临床上以消化道真菌感染多见,侵袭性真菌感染的病死率高。
Objective To analyze the incidence and clinical features of AIDS-associated invasive fungal infection and provide reference for its diagnosis and treatment. Methods The clinical data of 85 AIDS patients were retrospectively analyzed. The incidence and clinical features of invasive fungal infections were summarized. Results 85 cases of AIDS patients with invasive fungal infection in 35 cases, the infection rate was 41.2%, the site of infection mainly digestive tract, accounting for 44.4%, pathogenic bacteria Candida albicans (Candida albicans The main cases accounted for 57.4%. The cases of invasive fungal infections mainly occurred in 71.8% of patients with CD4 ~ + T lymphocyte counts <100 / μl. Twenty-seven of the 35 patients were cured and 8 died. Conclusion Invasive fungal infection is one of the major opportunistic infections in AIDS patients. The occurrence of invasive fungal infections is closely related to the CD4 ~ + T lymphocyte count. Clinically, gastrointestinal fungal infections are common and the mortality of invasive fungal infections is high.