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目的:建立过逸气虚证候大鼠模型;方法:60只雄性Wistar大鼠随机分为空白对照组、气虚模型组、人参组、薤白组,每组15只。空白对照组大鼠置于普通代谢笼中(单笼),饲以普通饲料;气虚模型组大鼠置于经改造过的代谢笼中(单笼),笼内空间以其保持基本安静且能转身移动为标准,饲以高营养饲料;人参组与薤白组大鼠于实验开始分别给予人参(1.2g生药.kg-1.d-1)与薤白(1.2g生药.kg-1.d-1)CMC-Na混悬溶液灌胃,1次/d,其他处理同气虚模型组。共计10周。实验结束后对大鼠生物学表征进行观察,并采用半定量评分表评分;测定大鼠力竭游泳时间。结果:与空白对照组比较,气虚模型组大鼠生物学表征明显改变,评分显著升高(P<0.01),力竭游泳时间显著缩短(P<0.01);与气虚模型组比较,人参组大鼠生物学表征明显改善,评分减少(P<0.05),力竭游泳时间显著延长(P<0.01);薤白组上述指标无显著性差异。结论:采用高营养饮食复合限制活动的方法可成功建立气虚证候动物模型。
PURPOSE: To establish a model of excessive qi deficiency syndrome in rats. Methods: Sixty male Wistar rats were randomly divided into blank control group, Qi deficiency model group, ginseng group and Xiong Bai group. The blank control group rats were placed in the normal metabolism cage (single cage), fed with normal feed; Qi deficiency model group rats were placed in a modified metabolic cage (single cage) cage space to keep it basically quiet and can (1.2g crude drug.kg-1.d-1) and whitebait (1.2g crude drug.kg-1.d-1) were given to the rats at the beginning of the experiment. 1) CMC-Na suspension solution gavage, 1 / d, other treatment with the Qi deficiency model group. Total 10 weeks. After the experiment, the biological characteristics of the rats were observed, and the semi-quantitative scoring system was used to measure the rats’ exhaustive swimming time. Results: Compared with the blank control group, the biological characteristics of the Qi deficiency model group changed significantly, the score was significantly increased (P <0.01) and the exhausted swimming time was significantly shorter (P <0.01). Compared with the Qi deficiency model group, The biological characteristics of rats were improved significantly, the score was decreased (P <0.05), and the time of exhaustive swimming was significantly prolonged (P <0.01). There were no significant differences in the above parameters between the control group and the control group. Conclusion: The animal model of qi deficiency syndrome can be successfully established by adopting the method of high nutritional diet and compound restriction activity.