应用第Ⅷ因子相关抗原免疫组化方法，对６４例肺癌组织内微血管定量与肺门淋巴结转移的关系进行了研究。结果发现鳞状细胞癌微血管定量为４８１７±２５４个／ＨＰ，腺癌为６９３２±２７２个／ＨＰ，小细胞癌为７７６６±２３２个／ＨＰ。鳞状细胞癌微血管定量明显低于小细胞癌（Ｐ＜０００１）；无淋巴结转移组微血管定量（５４５±１３５个／ＨＰ）明显低于有转移组（７６３±１４６个／ＨＰ）。提示肺癌组织中微血管生成与癌细胞分化程度有密切关系，微血管定量高的肺癌可能预后不良和易发生转移 Using VIII factor-associated antigen immunohistochemistry method, the relationship between microvessel quantification and hilar lymph node metastasis was studied in 64 patients with lung cancer. The results showed that the quantification of microvessels in squamous cell carcinoma was 4817±254/HP, adenocarcinoma was 6932±272/HP, and small-cell carcinoma was 7766±232/HP. The quantification of microvessels in squamous cell carcinoma was significantly lower than that in small cell carcinoma (P<0001); the quantification of microvessels in the group without lymph node metastasis (545±135/HP) was significantly lower than that in the metastatic group (763±14). 6/HP). It is suggested that angiogenesis in lung cancer tissues is closely related to the degree of cancer cell differentiation. Lung cancer with high quantification of microvessels may have a poor prognosis and may easily metastasize.