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目的探讨蒙古族人群炎症标志物C反应蛋白(CRP)、可溶性E选择素(sE-selectin)和可溶性细胞黏附分子(sICAM-1)与胰岛素敏感指数(ISI)的关系。方法以年龄≥20岁蒙古族居民作为研究对象,采取调查问卷方式收集人口统计学特征和生活方式危险因素资料,测量身高、体质量和血压,检测血脂、血糖、胰岛素和CRP、sE-se-lectin、sICAM-1等炎症标志物等指标。采用Logistic回归分析炎症标志物水平与ISI降低的关联关系。结果经多因素调整后,随着CRP和sE-selectin水平的升高,ISI降低的危险度呈升高趋势(P<0.05)。以最低分位为参比,最高分位CRP和sE-selectin者的ISI降低(ISI≤0.0130)的OR值(95%可信区间)为1.324(0.990～1.771)和1.986(1.486～2.654)。而sICAM-1水平升高与ISI降低的危险性无关联关系(P>0.05)。结论 CRP和sE-selectin水平升高与ISI降低的危险性相关联。
Objective To investigate the relationship between inflammatory response markers C-reactive protein (CRP), sE-selectin and sICAM-1 and insulin sensitivity index (ISI) in Mongolian population. Methods Mongolian residents aged 20 years and older were selected as research subjects. Demographic characteristics and lifestyle risk factors were collected by questionnaires. Height, body mass and blood pressure were measured. Blood lipids, blood glucose, insulin, CRP, sE-se- lectin, sICAM-1 and other indicators of inflammation and other indicators. Logistic regression was used to analyze the association of inflammatory markers with decreased ISI. Results After adjustment for multiple factors, the risk of ISI decreased with the increase of CRP and sE-selectin levels (P <0.05). The odds ratio (95% confidence interval) for ISI reduction (ISI ≤0.0130) for the highest quintile of CRP and sE-selectin was 1.324 (0.990 to 1.771) and 1.986 (1.486 to 2.654), respectively. There was no correlation between the increased sICAM-1 level and the risk of ISI reduction (P> 0.05). Conclusions Elevated levels of CRP and sE-selectin are associated with a decreased risk of ISI.