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体内、外实验证明,在位、异位的子宫内膜上皮细胞和间质细胞能合成、释放前列环素(PGI_2)和血栓素(TXA_2),并影响着子宫内膜异位症的病理生理整个过程。PGI_2、TXA_2及其某些代谢产物在病灶局部和盆腔液体中蓄积或比例失调,使子宫血管异常收缩造成子宫缺血和痉挛而致痛经,或抑制干扰排卵、影响黄体功能、输卵管异常蠕动而致不孕。前列腺素抑制剂(PGSI)能使PGI_2、TXAv2合成减少,改善痛经、不孕等症状。
In vitro and in vivo experiments show that endometrial epithelial cells and stromal cells in eutopic and ectopic endometrium can synthesize and release prostacyclin (PGI_2) and thromboxane (TXA_2) and affect the pathophysiology of endometriosis the whole process. PGI_2, TXA_2 and some of its metabolites in the lesion and pelvic fluid in the accumulation or proportion of disorders, uterine blood vessels caused by abnormal contraction caused by ischemia and spasm caused by dysmenorrhea, or interfere with ovulation, affecting luteal function, tubal abnormalities caused by peristalsis Infertility. Prostaglandin inhibitor (PGSI) can reduce PGI_2, TXAv2 synthesis, improve dysmenorrhea, infertility and other symptoms.