目的研究ｐ１６抑癌基因蛋白与子宫内膜癌的关系。方法应用免疫组化ＳＰ法对６４例子宫内膜癌、２２例非典型增生内膜和３０例正常内膜组织做ｐ１６蛋白检测。结果ｐ１６在内膜癌中阳性率为４６．８７％，明显低于正常内膜１００％和非典型增生７２．７３％（Ｐ＜０．０１，Ｐ＜０．０５）。结论ｐ１６蛋白的缺失与突变可能与内膜癌的发生、发展密切相关，是检测内膜癌的重要标志。 Objective To study the relationship between p16 tumor suppressor gene and endometrial cancer. Methods Immunohistochemical SP method for 64 cases of endometrial cancer, 22 cases of atypical hyperplasia endometrium and 30 cases of normal endometrial tissue p16 protein detection. Results The positive rate of p16 in endometrial carcinoma was 46.87%, which was significantly lower than that in normal endometrium and atypical hyperplasia (P <0.01, P <0.05). Conclusion The deletion and mutation of p16 protein may be closely related to the occurrence and development of endometrial carcinoma, which is an important marker of detecting endometrial carcinoma.