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目的对经盐酸表阿霉素脂质体治疗的S180荷瘤小鼠生命质量进行研究,为抗癌药物脂质体药效的评价提供一种新的方法。方法以小鼠摄水量、摄食量、体质量、自主活动次数和爬网时间为指标,评价经盐酸表阿霉素溶液及盐酸表阿霉素脂质体治疗的S180荷瘤小鼠生命质量。结果与盐酸表阿霉素溶液相比,经盐酸表阿霉素脂质体治疗后S180荷瘤小鼠生命质量得到改善。结论在以荷瘤小鼠为研究对象进行抗癌药物脂质体药效学研究时,生命质量是一种评价药物治疗效果的重要指标。
OBJECTIVE To study the quality of life of S180 tumor-bearing mice treated with epirubicin hydrochloride liposomes, and to provide a new method for evaluating the efficacy of anticancer drug liposomes. Methods The water intake, body weight, times of spontaneous activity and time of crawling in mice were used as indicators to evaluate the quality of life of S180 tumor-bearing mice treated with epirubicin hydrochloride and epirubicin hydrochloride liposomes. Results Compared with epirubicin hydrochloride solution, the quality of life of S180 tumor-bearing mice was improved after epirubicin hydrochloride liposome treatment. Conclusion In the study of liposomal pharmacodynamics of anticancer drugs in tumor-bearing mice, quality of life is an important index to evaluate the therapeutic effect of drugs.