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目的:研究脑梗死患者颈动脉粥样斑块与胆红素和纤维蛋白原之间的关系。方法:对110例脑梗死住院患者通过颈动脉多普勒超声确定有无颈动脉斑块,根据斑块的有无分为斑块组(72例)和无斑块组(38例)。2组之间性别、年龄比较无显著差异(P>0.05)。同时测定胆红素和纤维蛋白原水平,调查血糖、血脂及高血压等其他危险因素。结果:斑块组血胆红素,尤其是间接胆红素明显低于无斑块组,有统计学意义(P<0.05),纤维蛋白原明显高于无斑块组,有统计学意义(P<0.05)。结论:低血清胆红素、高纤维蛋白原水平为颈动脉斑块形成和发展的重要危险因素。
Objective: To study the relationship between carotid artery plaque and bilirubin and fibrinogen in patients with cerebral infarction. Methods: One hundred and ten hospitalized patients with cerebral infarction were divided into plaque group (72 cases) and no plaque group (38 cases) by carotid artery Doppler ultrasound to determine the presence or absence of carotid artery plaque. There was no significant difference between the two groups in gender and age (P> 0.05). Simultaneous determination of bilirubin and fibrinogen levels, to investigate other risk factors such as blood glucose, blood lipids and hypertension. Results: Serum bilirubin, especially indirect bilirubin, was significantly lower in plaque group than in non-plaque group (P <0.05), and fibrinogen was significantly higher in non-plaque group (P <0.05) P <0.05). Conclusion: Low serum bilirubin and high fibrinogen levels are important risk factors for the formation and development of carotid plaques.