近日,韩国三星先进研究院利用宏基因组筛选和人工设计开发出一条可生产丙烯酸的生物路线,该成果发表于国际知名学术期刊《代谢工程》。该研究通过宏基因组筛选和人工设计获得由3-羟基丙酸(3-HP)、3-羟基丙酸辅酶A和丙烯酰辅酶A直接生产丙烯酸的生物合成途径。与化工合成路线不同,新途径转化过程中 Recently, the Samsung Advanced Research Institute of Korea used metagenomic screening and manual design to develop a biological route that can produce acrylic acid. The achievement was published in the internationally renowned academic journal Metabolic Engineering. This study obtained a biosynthetic pathway for the direct production of acrylic acid from 3-hydroxypropionic acid (3-HP), 3-hydroxypropionic acid coenzyme A and acrylyl-CoA through metagenomic screening and manual design. Different from the route of chemical synthesis, the new way is transformed