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检测了57例糖尿病患者和83例正常对照者的血、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活性。发现糖尿病患者NAG活性显著高于对照组(P＜0.01)，与同时测定的血糖、糖化血红蛋白(HbA_(1c))、尿白蛋白呈显著正相关(P均＜0.01)，治疗后随血糖下降尿NAG活性降低，但有微血管病变组仍显著高于正常对照组。提示NAG活性是反映糖尿病性微血管病变程度的一项指标。
Blood and urinary N-acetyl-β-D-glucosaminidase (NAG) activity were measured in 57 diabetics and 83 normal controls. It was found that the activity of NAG in diabetic patients was significantly higher than that of the control group (P <0.01), and positively correlated with the levels of blood glucose, HbA 1c and urine albumin (P <0.01) Urinary NAG activity decreased, but microvascular lesions group was still significantly higher than the normal control group. Tip NAG activity is an indicator of the degree of diabetic microangiopathy.