妊娠期肝病主要分为两类:一类与妊娠同时发生,但病原学上与妊娠无关;另一类特发于妊娠期,终止妊娠可获得痊愈。本文主要论述后一类肝病的临床病理学特征,如妊娠急性脂肪肝、妊娠中毒症肝病、妊娠肝内胆汁郁积以及妊娠剧烈呕吐。一、妊娠急性脂肪肝发生于妊娠末三月,特别是妊娠35周后,多见于经产妇,双胎和孕妇易受累,是妊娠肝病中最严重的疾病。延误诊断或处理不及时,可发展到暴发性肝功衰竭、肝性脑病、弥漫性血管内凝血(DIC)、不能控制的胃肠道出血和子宫出血,直至死亡。七十年代末本病的母、胎死亡率分别高达75%和85%。近年由于早期病例的认识和强有力的治疗, Gestational liver disease is mainly divided into two categories: one with pregnancy occurs simultaneously, but etiologically and pregnancy has nothing to do; the other type of idiopathic pregnancy, termination of pregnancy can be cured. This article discusses the clinical and pathological features of the latter group of liver diseases, such as acute fatty liver of pregnancy, liver disease of gestosis, pregnancy intrahepatic cholestasis and severe vomiting in pregnancy. First, acute fatty liver of pregnancy occurs in the last trimester of pregnancy, especially after 35 weeks of pregnancy, more common in the mothers, twins and pregnant women susceptible to fatigue, is the most serious liver disease in pregnancy disease. Delay in diagnosis or treatment is not timely, can develop to fulminant hepatic failure, hepatic encephalopathy, diffuse intravascular coagulation (DIC), uncontrollable gastrointestinal bleeding and uterine bleeding until death. At the end of the seventies this disease mother and child mortality rates were as high as 75% and 85%. In recent years, due to the understanding of early cases and powerful treatment,