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目的分析急性脑血管病并发神经源性肺水肿血清中儿茶酚胺(CA)含量与血清钠尿肽(BNP)水平变化及血清中白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平变化。方法选择2013年8月-2015年4月诊断急性脑血管病并发神经源性肺水肿患者60例作为观察组,取同期急性脑血管病不伴有神经源性肺水肿患者60例作为对照组。入院后24h内采用酶联免疫分析法检测血清中CA含量,免疫化学发光法检测血清中BNP水平,利用Pearson直线相关分析比较CA与BNP之间相关性。入院后于6h、12h、24h、48h、72h采用酶联免疫吸附法检测血清中IL-6、TNF-α水平的动态变化。结果观察组血清CA与BNP水平明显高于对照组,差异均有统计学意义(P<0.05),CA与BNP之间呈中度直线相关(r=0.715,P<0.05)。入院后6h、12h、24h、48h、72h观察组IL-6、TNF-α水平呈逐渐上升变化,于24h达峰后逐渐下降,差异均有统计学意义(P<0.05)。结论急性脑缺血性脑血管病并发神经源性肺水肿患者血清CA与BNP水平明显升高,二者呈中度直线相关,发病后血清IL-6与TNF-α呈逐渐升高后下降趋势,血清炎性介质水平变化与神经源性肺水肿的发生存在一定关系。
Objective To analyze the levels of serum catecholamine (CA) and serum level of natriuretic peptide (BNP) in patients with acute cerebrovascular disease complicated with neurogenic pulmonary edema and the levels of interleukin-6 (IL-6), tumor necrosis factor- Change in level. Methods Sixty patients diagnosed as acute cerebrovascular disease complicated with neurogenic pulmonary edema from August 2013 to April 2015 were selected as observation group and 60 patients with acute cerebrovascular disease without neurogenic pulmonary edema as control group. Serum CA levels were detected by enzyme-linked immunosorbent assay (ELISA) within 24 hours after admission. The level of serum BNP was detected by immunochemical chemiluminescence. Pearson’s linear correlation analysis was used to compare the correlation between CA and BNP. Serum levels of IL-6 and TNF-α were detected by enzyme-linked immunosorbent assay at 6h, 12h, 24h, 48h, 72h after admission. Results The levels of serum CA and BNP in the observation group were significantly higher than those in the control group (P <0.05). There was a moderate linear correlation between CA and BNP (r = 0.715, P <0.05). The levels of IL-6 and TNF-α gradually increased at 6h, 12h, 24h, 48h, 72h after admission, and gradually decreased at the peak of 24h after admission. The difference was statistically significant (P <0.05). Conclusions The levels of serum CA and BNP in patients with acute cerebral ischemic cerebrovascular disease complicated with neurogenic pulmonary edema were significantly increased. There was a moderate linear correlation between the two. Serum IL-6 and TNF-α levels gradually decreased and then decreased Serum levels of inflammatory mediators have some relationship with the occurrence of neurogenic pulmonary edema.