高分压氧产生的过量活性氧自由基是导致氧毒性的最主要损伤机制,这限制了氧在临床上的广泛应用。线粒体是氧代谢的主要场所,这使其成为活性氧自由基产生及引起损伤的主要部位,而线粒体的严重损伤会导致细胞死亡。近年研究证实氢气能够选择性地清除毒性作用极强的自由基,对高分压氧毒性所致的线粒体损伤有保护作用,从而保护细胞免受自由基损害。该文重点阐述高分压氧毒性所致的线粒体损伤及氢气的拮抗作用。 Excessive reactive oxygen species generated by hyperbaric oxygen is the most important damage mechanism leading to oxygen toxicity, which limits the widespread use of oxygen in the clinic. Mitochondria are the major sites of oxygen metabolism, making it a major site for reactive oxygen species to produce and cause damage, and severe damage to mitochondria leads to cell death. Recent studies have confirmed that hydrogen can selectively remove the extremely toxic free radicals, the protective effect of mitochondrial damage caused by high partial pressure oxygen toxicity, thereby protecting cells from free radical damage. This article focuses on mitochondrial damage induced by hyperbaric oxygen toxicity and antagonism of hydrogen.