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以一种新型的免疫抑制剂———霉酚酸酯联合小剂量强的松治疗５ 例儿童难治性肾病综合征取得了较好的效果，未见明显的毒副作用，特别是对２ 例环磷酰胺拮抗的狼疮性肾炎不仅临床症状完全消失，而且血沉、免疫球蛋白、循环免疫复合物、血清自身抗体及补体均恢复正常。结论：霉酚酸酯是治疗儿童难治性肾病综合征特别是环磷酰胺拮抗的难治性Ⅳ型狼疮肾的一种有前途的药物。
With a new type of immunosuppressant --- mycophenolate combined with low-dose prednisone in 5 cases of children with refractory nephrotic syndrome has achieved good results, no significant side effects, especially in 2 cases Cyclophosphamide antagonistic lupus nephritis not only completely disappeared clinical symptoms, and ESR, immunoglobulin, circulating immune complexes, serum autoantibodies and complement were back to normal. CONCLUSIONS: Mycophenolate mofetil is a promising drug for the treatment of intractable nephrotic syndrome in children, especially refractory cyclophosphamide-resistant lupus nephropathy.