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奴佛卡因溶液的含量测定我省多年来一直没有统一标准测定方法,各方法均存在不同程度的误差,且操作费时,终点不易掌握。本文根据奴佛卡因溶液组成成分的特点,参考有关资料拟定了以紫外分光光度法直接测定奴佛卡因溶液含量的方法,结果与中国药典规定的原料含量测定重氮化的水停滴定法比较相接近。实验证明:本法操作简便,快速、准确,回收率101.60％,变异系数0.59％,适用于基层,有利于对该制剂的质量控制。
Determination of the content of novocaine solution in our province has been no uniform standard for many years of determination, the methods are different levels of error, and the operation time-consuming, the end is not easy to grasp. In this paper, according to the characteristics of novocaine solution composition, with reference to the relevant data developed a method for the determination of the content of novocaine directly UV spectrophotometry, the results with the Chinese Pharmacopoeia Determination of the raw material determination of diazotization of water stop titration More close. Experiments show that this method is simple, rapid and accurate. The recovery rate is 101.60% and the coefficient of variation is 0.59%. It is suitable for the grass roots and is good for the quality control of this preparation.