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目的：观察甘糖酯及胰岛素对体外孵育红细胞变形性（ＥＤ）的影响。方法：对１２例ＩＩ型糖尿病（ＮＩＤＤＭ）病人（男性６例，女性６例，年龄６０±ｓ１０ａ）取血观察其ＥＤ，并与正常人比较。将红细胞分别与甘糖酯和胰岛素共同孵育２４ｈ观察ＥＤ变化。结果：病人的ＥＤ明显低于正常人。孵育２４ｈ后，ＥＤ进一步降低。但与甘糖酯孵育后ＥＤ较孵育前改善。与胰岛素共同孵育后，ＥＤ较孵育前降低，但较不加药物孵育者降低程度小。结论：甘糖酯在体外可使ＮＩＤＤＭ病人ＥＤ改善。胰岛素的作用较弱。
Objective: To observe the effects of glyceryl ester and insulin on erythrocyte deformability (ED) in vitro. Methods: The ED of 12 patients with type 2 diabetes mellitus (NIDDM) (6 males and 6 females, age 60 ± s10a) were collected and compared with normal controls. Erythrocytes were co-incubated with glyceryl ester and insulin for 24h to observe the changes of ED. Results: The patient’s ED was significantly lower than normal. After incubation for 24 h, ED was further reduced. However, the ED after incubation with mannose ester improved than before incubation. After incubation with insulin, ED decreased compared with that before incubation, but decreased less than that without drug. Conclusion: Glyceryl ester can improve ED in patients with NIDDM in vitro. The effect of insulin is weak.