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用细胞内微电级和电压钳技术研究了２［对－（二甲氨基）苯乙烯］碘化甲基砒啶（ＤＳＰＭ）对豚鼠乳头肌慢反应动作电位（ＳＲＡＰ，）和慢内向电流（Ｉｓｉ）的影响。用ＤＳＰＭ液灌流５０分钟后，高Ｋ￣＋所致ＳＲＡＰ的振幅和零相最大上升速率均显著降低，Ｉｓｉ的峰值由８．８±１．６μＡ降至５．７±１．８μＡ。上述结果表明ＤＳＰＭ具有选择性阻断钙通道的作用
The effects of 2 [p- (dimethylamino) styrene] methylpyridinium iodide (DSPM) on the slow response action potentials (SRAP) and slow inward current of guinea pig papillary muscles Isi). After 50 min of perfusion with DSPM solution, the amplitude of SRAP induced by high K ~ + and the maximum rate of zero phase decrease significantly, and the peak value of Isi decreased from 8.8 ± 1.6μA to 5.7 ± 1.8μA. The above results indicate that DSPM has the effect of selectively blocking calcium channels