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在早些年对于研制出对病毒具有选择性毒性药物的可能性是悲观的.这是因为病毒和宿主细胞的复制似乎密切相关.然而,近廿年来已很清楚,一些病毒的摄入和复制有其独特的过程,从而可能有目标地研制出专门针对这些生理过程的药物.目前这类药中的某些已有了进展,特别抗疱疹病毒药物取得了明显的成功.疱疹病毒在一般居民中为重要致病源,并在免疫受损的病人中可致死亡.本文复习了特别是对疱疹病毒有效药物的作用机理和临床作用.
Pessimistic about the possibility of developing drugs that are selective for the virus in the early years is because the virus appears to be closely related to the replication of the host cell, however, it has become clear for some 20 years that some virus uptake and replication Has its own unique process that may have targeted the development of specific drugs for these physiological processes.At present some of these drugs have made progress, in particular the anti-herpes virus drugs have achieved significant success Herpes simplex virus in the general population Is an important causative agent and causes death in immunocompromised patients.This paper reviews the mechanism of action and clinical utility, especially for herpes simplex virus-effective drugs.