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60年代末Seeney等首先报道唾液胰岛素测定,且与血浆胰岛素有相关,随后Vallejo等采用物理化学及放射免疫技术证实胰岛素是通过积聚超滤方式从血液向唾液运转.近年来,Marchetti等观察了正常人肥胖者、非胰岛素依赖型糖尿病(NIDDM)糖负荷后,及胰岛素依赖型糖尿病者(IDDM)注射胰岛素后,多点测定唾液胰岛素(S-INS),其结果均能反映血浆胰岛素(P-INS)水平.唾液取材方便,便于动态观察.本文对伴与不伴肥胖的正常人、NIDDM者作据负荷后NJS-INS与P-INS水平间观察,以初探临床应用及意义.
In the late 60s Seeney et al first reported salivary insulin determination, and is associated with plasma insulin, followed by Vallejo and other physicochemical and radioimmunoassay confirmed that insulin by accumulating ultrafiltration from blood to saliva operation.In recent years, Marchetti other observed normal Human obesity, non-insulin-dependent diabetes mellitus (NIDDM) sugar load, and insulin-dependent diabetes mellitus (IDDM) after insulin injection, saliva insulin (S-INS) INS) levels.Saliu convenient access for dynamic observation.This article for non-obese with and without obesity in normal people, NIDDM were under load after the load of NJS-INS and P-INS levels to explore the clinical significance and application.