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目的观察拉西地平与小剂量双氢克尿噻联用治疗老年单纯收缩期高血压疗效及不良反应。方法入选126例年龄≥60岁单纯收缩期高血压病患者随机分为三组。A组拉西地平4mg/d,双氢克尿噻12.5mg/d联用;B组拉西地平4mg/d;C组双氢克尿噻25mg/d;各组疗程均为4周。结果A组显效34例(81%),有效6例(14%),无效2例(5%),总有效率95%;B组显效21例(50%),有效10例(24%),无效11例(26%),总有效率74%;C组显效13例(31%),有效13例(31%),无效16例(38%),总有效率67%。结论拉西地平与小剂量双氢克尿噻联用治疗老年单纯收缩期高血压疗效显著,不良反应少。
Objective To observe the efficacy and adverse reactions of lacidipine combined with low-dose hydrochlorothiazide in the treatment of isolated systolic hypertension in the elderly. Methods 126 cases of age ≥ 60 years of isolated systolic hypertension were randomly divided into three groups. A group of lacidipine 4mg / d, hydrochlorothiazide 12.5mg / d combination; B group raxiridipine 4mg / d; C group hydrochlorothiazide 25mg / d; each course of treatment were 4 weeks. Results The effective rate of group A was 34 cases (81%), 6 cases (14%) were effective, 2 cases (5%) were ineffective and the total effective rate was 95% (26%) were ineffective and the total effective rate was 74%. In group C, 13 cases were markedly effective (31%), 13 cases were effective (31%), 16 cases were ineffective (38%), and the total effective rate was 67%. Conclusion The effect of lacidipine combined with low-dose hydrochlorothiazide therapy on senile isolated systolic hypertension is significant and there are few adverse reactions.