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TRIM5α是一种具有3个结构域的胞浆体蛋白质。新近发现猿猴细胞中的TRIM5α具有抗HIV-1的作用,从而使TRIM5α的研究引起广泛关注。本文对TRIM5α的分子结构特点、抗HIV1的作用、抗病毒机制及其相似蛋白质的功能等方面的最新研究进展作一综述。
TRIM5α is a three-domain cytoplasmic protein. Recently, it has been found that TRIM5α in simian cells has an anti-HIV-1 effect, so that the research on TRIM5α attracts much attention. This review summarizes the molecular structure of TRIM5α, the anti-HIV1 effect, the anti-viral mechanism and the function of its similar proteins.