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1972年 Mayer 将正常人肝细胞匀浆经过 Sepha-dex G100 和 Sephadex G200 凝胶过滤后获得显示肝特异性抗原的蛋白质 LP_1 和 LP_2。LP_1 是肝细胞膜成分,分子量约100万道尔顿,含有磷酯和甘油三酯及多种蛋白成分,后改称肝特异性脂蛋白(LSP).
In May, 1972, normal liver cell homogenates were gel-filtered through Sephadex G100 and Sephadex G200 to obtain LP1 and LP2 proteins that showed liver-specific antigen. LP_1 is a component of the liver cell membrane, molecular weight of about 1 million Daltons, containing phospholipids and triglycerides and a variety of protein components, later renamed liver-specific lipoprotein (LSP).