论文部分内容阅读
为研究胰岛素依赖型糖尿病（ＩＤＤＭ）和非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者中脂蛋白（ａ）［Ｌｐ（ａ）］水平的变化，选择１８例ＩＤＤＭ患者和７６例ＮＩＤＤＭ患者用酶联免疫法（ＥＬＩＳＡ）测定Ｌｐ（ａ），并用２０例非糖尿病作对照。结果：ＩＤＤＭ患者的Ｌｐ（ａ）水平与非糖尿病对照无明显差异，ＮＩＤＤＭ患者的Ｌｐ（ａ）水平仅有上升的趋势，而其中高胰岛素组患者的Ｌｐ（ａ）水平则明显升高。在两组糖尿病患者中，伴有微量蛋白尿者的Ｌｐ（ａ）水平明显高于无蛋白尿的糖尿病患者和非糖尿病对照者。提示胰岛素水平较高和早期肾脏病变的糖尿病患者可能有较高水平的Ｌｐ（ａ）。
To investigate the changes of lipoprotein (a) [Lp (a)] levels in patients with and without insulin-dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus (IDDM), 18 patients with IDDM and 76 patients with NIDDM were enrolled in this study. (ELISA) Lp (a), and 20 cases of non-diabetic control. Results: There was no significant difference in Lp (a) level between IDDM and nondiabetic controls. The Lp (a) level in NIDDM patients only showed an increasing tendency, while the Lp (a) level in patients with high insulin group was significantly higher than that in nondiabetic controls. In both groups of patients with diabetes, Lp (a) levels were significantly higher in patients with microalbuminuria than those without proteinuria and non-diabetic controls. Suggesting that patients with diabetes who have high insulin levels and early kidney disease may have a higher level of Lp (a).