论文部分内容阅读
目的探讨高FSH是否能做为Y染色体微缺失的独立检测指针。方法回顾性分析2011年-2014年间409例绍兴地区生殖门诊男性患者的性激素水平和同期294例患者Y染色体微缺失情况。结果 294例行Y染色体微缺失检测的患者中,有12例(4.08%)发现Y染色体微缺失,其中4例为AZFc区(AZFc-SY255,AZFc-SY254)和AZFb区(AZFb-SY127,AZFbSY134)均缺失,8例只存在c区(AZFc-SY255,AZFc-SY254)缺失。FSH值在Y染色体微缺失的病例和407例生育异常男性患者中有明显差异(11.13±6.32m IU/ml vs 4.18±4.06m IU/ml,P<0.001),FSH值(大于10 m IU/ml)的比例在总生育异常男性人群和Y染色体微缺失组中分别为5.37%vs 54.54%,差异有显著性(P<0.005)。结论 Y染色体微缺失者FSH水平异常比例高,FSH可做为Y染色体微缺失检测的一项单独预测指征。
Objective To investigate whether high FSH can be used as an independent test indicator of Y chromosome microdeletion. Methods A retrospective analysis of sex hormones in 409 male patients in reproductive clinics in Shaoxing from 2011 to 2014 and Y chromosome microdeletions in 294 patients during the same period were retrospectively analyzed. RESULTS: Of the 294 patients with Y-chromosome microdeletion, 12 (4.08%) had Y chromosome microdeletions, of which 4 were AZFc (AZFc-SY255, AZFc-SY254) and AZFb (AZFb-SY127, AZFbSY134 ) Were missing, only 8 cases of c area (AZFc-SY255, AZFc-SY254) is missing. There was a significant difference in the value of FSH between the cases of Y chromosome microdeletions and the 407 cases of males with abnormal fertility (11.13 ± 6.32m IU / ml vs 4.18 ± 4.06m IU / ml, P <0.001) ml) was 5.37% vs 54.54% in the total fertility male and Y chromosome microdeletions, respectively, with significant difference (P <0.005). Conclusion The abnormal proportion of FSH in Y chromosome microdeleted persons is high. FSH can be used as a separate predictor of Y chromosome microdeletion.