目的 :探讨经皮椎体成形术对脊柱转移瘤患者临床效果观察及安全性评价。方法 :74例患者按照随机数字表法随机分为两组,分别为对照组(n=37)和观察组(n=37)。对照组采用传统开放手术治疗,观察组采用经皮椎体成形术治疗。对比分析两组患者术前、术后1d、术后10d、术后1个月、术后3个月、术后6个月VAS评分及有效率。结果 :两组术后1d、术后10d、术后1个月、术后3个月、术后6个月VAS评分较治疗前显著降低;观察组术后1d、术后10d、术后1个月、术后3个月、术后6个月VAS评分治疗后显著低于同期对照组;观察组术后1d、术后10d、术后1个月、术后3个月及术后6个月有效率显著高于同期对照组。结论 :经皮椎体成形术对脊柱转移瘤患者临床效果显著,可明显减轻患者疼痛,临床应用安全可靠,值得临床进一步推广应用。 Objective: To investigate the clinical effect and safety evaluation of percutaneous vertebroplasty on patients with spinal metastases. Methods: Totally 74 patients were randomly divided into two groups according to random number table: control group (n = 37) and observation group (n = 37). The control group was treated by traditional open surgery and the observation group by percutaneous vertebroplasty. The VAS score and effective rate of the two groups before operation, 1 day after operation, 10 days after operation, 1 month after operation, 3 months after operation and 6 months after operation were compared. Results: The VAS score at 1 day after operation, at 10 days after operation, at 1 month after operation, at 3 months after operation and at 6 months after operation were significantly lower than those before operation in the two groups. The scores of VAS at 1 day after operation, 10 days after operation, Month, 3 months after operation and 6 months after operation. The VAS score in the observation group was significantly lower than that in the control group at 1 day after operation, 10 days after operation, 1 month after operation, 3 months after operation and 6 Month efficiency was significantly higher than the control group over the same period. Conclusion: Percutaneous vertebroplasty has significant clinical effect on patients with spinal metastases, which can significantly reduce the pain of patients and the clinical application is safe and reliable, so it is worth further clinical application.