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研究证实,丙戊酸可导致癫痫病人体重明显增加,其机制尚未完全明确,可能与胰岛素和瘦素水平的变化有关。文章就近年来丙戊酸对胰岛素、瘦素水平的影响的研究结果进行了综述。
Studies have shown that valproic acid can cause significant weight gain in patients with epilepsy, the mechanism is not yet fully clear, may be related to changes in insulin and leptin levels. In this paper, the effects of valproic acid on insulin and leptin levels in recent years are summarized.