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本文报告应用不同剂量的单纯或复方炔诺酮庚酸酯长效避孕针的临床药理学研究结果。所用剂量为:炔诺酮庚酸酯80mg/50mg分别配伍戊酸雌二醇5mg,每月肌注一次及单纯炔诺酮庚酸酯200mg每二个月肌注一次,使用以上三种针剂的妇女数分别为2523例、27816个周期;625例、5934个周期及3242例、29944个周期。其妊娠率分别为0.04、0.20及1.4%。按生命表法算得三组的年累积连续用针率为75.9、81.7及59.2%。因不规则出血所致停针率分别为11.9、6.6及24.2%,而闭经引起的停针率则为3.5、2.9及7.5%。结果表明炔诺酮庚酸酯50mg配伍戊酸雌二醇5mg的复方针剂为一很有希望的长效注射避孕剂。
This article reports the application of different doses of simple or compound norethisterone acetate long-acting contraceptive clinical pharmacology findings. The dosage used is: norethindrone heptanoate 80mg / 50mg, respectively, with valerate valerate 5mg, intramuscular injection once a month and norethindrone acetate 200mg once every two months intramuscular injection, the use of the above three kinds of injection The number of women was 2523 cases, 27816 cycles; 625 cases, 5934 cycles and 3242 cases, 29944 cycles. The pregnancy rates were 0.04, 0.20 and 1.4% respectively. Calculated by the life table method of three groups of cumulative cumulative rate of 75.9%, 81.7% and 59.2%. The needle-stop rates due to irregular bleeding were 11.9, 6.6 and 24.2%, respectively, while the rates of needle-stop due to amenorrhea were 3.5, 2.9 and 7.5% respectively. The results showed that norethisterone enantate 50mg with valerate valerate 5mg compound injection is a promising long-acting injection of contraceptives.